The oxygen concentration in the atmosphere as recorded at the Mauna Loa observatory (link). It is going down and the obvious explanation is that it is the result of our burning of fossil fuels. But do we risk to suffocate ourselves in this way? Fortunately, that's very unlikely, at least in the short run. However, looking at the "other side" of the carbon dioxide emission story gives us a good perspective of what's going on with the ecosystem as the result of human activities.
Everyone is worried about global warming, and correctly so. However, there is another side to the warming question: for every additional molecule of carbon dioxide (CO2) generated by burning fossil fuels, one molecule of oxygen (O2) must be consumed. That means less and less oxygen in the atmosphere. So, won't suffocation be an additional problem to global warming? (some people seem to be actually worried that it could be)
Fortunately, the answer is "no." We don't risk to run out of oxygen; at least in the short run. But the story is not simple and we can learn a lot about what's happening to our atmosphere, our climate, and our ecosystem if we look at the question in some detail.
First of all, what do we mean as "suffocation"? The present concentration of oxygen in the atmosphere is 21% in volume. We have evolved to live with this level of oxygen and the minimum level for humans to function normally is around 19% (See here). We are already in trouble below 17% and simply can't survive below 10%. So, we have to be careful with what we do with our atmosphere; we can't afford to lose more than about 10% of the oxygen we have, or about 1%-2% in volume present in the atmosphere.
Now, how much oxygen have we consumed with burning fossil fuels, so far? Not much, really. The data indicate a 0.05% volume loss of oxygen from 1990 to 2013. Clearly, we are not suffocating, at least not right now. However
But we need to go more in depth in the matter. Consider that we have been burning fossil fuels for a long time before 1990. We can roughly calculate the total loss considering that the concentration of carbon dioxide in the atmosphere has increased of about 120 parts per million in volume over the past century. A similar amount has been absorbed in the oceans, so we can say that we have produced the equivalent of ca. 250 ppm of CO2 and hence some 250 parts per million of oxygen (0.025% of the total volume of the atmosphere) must have gone in more than a century. But we are still well within the safety limits.
How about the future? The Keeling results tell us that, at the present rates, we consume about 0.02% of our oxygen every ten years. To arrive to lose the 1% which represents the safety threshold we would need centuries but, of course, we will not be able to keep burning fossil fuels at the present rates for such a long time. As we roll on the other side of the Hubbert curve, we won't probably be able to do more than double the amount already emitted (and perhaps much less, according to the Seneca scenario that sees decline much faster than growth). Even in the most extreme assumptions we could emit no more than some four times the amount produced so far. That would correspond to a loss of about 0.2% of the total oxygen available. Not negligible but, as far as we know, not harmful for humans.
So, burning fossil fuels would definitely not suffocate us; not directly, at least. But there are indirect effects. One is the loss of biomass caused by human activities. When plants and animals die, the carbon they contain is normally oxidized to carbon dioxide, consuming oxygen in the process. The total amount of carbon stocked in living creatures and soil is estimated as about 2100 billion tons (Gtons). If all this carbon were to react with oxygen, it would consume some 5600 Gtons of oxygen (taking into account that an atom of oxygen weighs more than an atom of carbon and that one atom of carbon consumes two atoms of oxygen). The total mass of oxygen in the atmosphere is calculated as of the order of 1.2x10^9 Gtons (see also this reference). So, even the total burning of the planetary ecosphere would make only a small dent in the total oxygen concentration; about 0.4% loss. And that, of course, is an extreme hypothesis that would see the whole biosphere destroyed - in this case, suffocation would be the least important problem.
We could consider also the release of the methane hydrates stored in permafrost; something that could happen as a result of global warming. Methane is a strong greenhouse gas, and so the process reinforces itself, that's the origin of the so called "methane catastrophe" that would result in a disastrous greenhouse runaway effect. The total mass of methane stored in permafrost is estimated as of the order of 500-2500 gtons of carbon. In the worst case, methane could consume another ca. 0.4% of the atmospheric oxygen.
Summing up everything we have considered so far, methane, organic matter, fossil fuels, we see that we don't go over the 1% threshold, even making rather extreme hypotheses. So, we would seem to be on the safe side. However, we should also take into account that by far the largest stock of organic (and hence burnable) carbon in the Earth's crust is in the form of "kerogen", the result of the partial decomposition of organic matter. (Figure below from Manicore.com).
10^16 tons of kerogen is such a large value that if all of it were to combine with oxygen (about 10^9 tons), then there won't be any oxygen left in the atmosphere. That would be, indeed, the "great suffocation".
Fortunately, that is unlikely to happen. Kerogen can react with oxygen and it is, actually, the original source of the petroleum we extract and burn today. But the natural process is very slow and the human-made one very expensive. With the best of good will, Kerogen is a very bad fuel. So, human beings won't be able, ever, to burn more than a microscopic fraction of the kerogen of the earth's crust.
So, oxygen loss, the great suffocation, is not something we should be worried about because we have much more oxygen in the atmosphere than what we could consume even in the worst possible hypothesis. We have this safety margin because free oxygen is the result of billions of years of photosynthetic activity which pumped lots of oxygen in the atmosphere. Of this oxygen, most was absorbed in inorganic oxides; principally iron oxides. Only a small fraction has gradually accumulated in the atmosphere, as we see in the following figure. (from Wikipedia - take into account that there is a big uncertainty in these estimates)
Note that a peak in the oxygen concentration was reached in the remote past, perhaps in correspondence with the peak in planetary biological productivity. At the peak, oxygen concentration may have reached a value of over 30% in volume - humans could not have survived in those conditions! Then, it may have gone down to about 15% and, again, we wouldn't have been able to survive with that concentration.
So, oxygen is not simply accumulating in the atmosphere to remain there forever. It is a reactive gas and its concentration is linked to the evolution of the ecosystem. There are factors that can strongly change its concentration, probably involving reaction with the kerogen stock. We can't know for sure what factors cause this reaction but a new dip in oxygen concentration as the result of the ongoing planetary changes cannot be excluded - even though that would probably be extremely slow by human standards. What we can be sure about is that we should be careful in the way we treat the Earth's ecosystem - we are part of it!